This can lower the level of Abilify in your system, which can make it less effective.Įxamples of strong CYP3A4 inducers. Drugs that are strong inducers of this enzyme speed up the removal of Abilify. CYP3A4 helps remove Abilify from your body. Taking Abilify with a strong CYP3A4 inducer can make Abilify less effective at treating your condition. Drugs that are strong CYP3A4 inducers increase the activity of this enzyme. Strong CYP3A4 inducersĬYP3A4 is an enzyme in your liver that helps remove certain drugs from your body. It slowly releases the medication into your blood over a month. * Abilify Maintena is a form of Abilify that’s given as an intramuscular injection. Your doctor or pharmacist can tell you more about Abilify and strong CYP3A4 and CYP2D6 inhibitors. During this time, the level of Abilify Maintena in your body will still be within the range required for treatment. If you need to take the inhibitor short term (less than 14 days), it will not impact how much Abilify Maintena you receive. This means you could be at an increased risk for certain side effects. A therapeutic level is the amount of drug in your system needed to properly treat your condition or disease. Long-term use of the inhibitor results in Abilify Maintena increasing above the therapeutic level in your body. The situation is if you take the inhibitor for longer than 14 days. However, if you receive Abilify Maintena* and take one of these inhibitors, your doctor will usually decrease the Abilify Maintena dosage only in a certain situation. If you take Abilify or Abilify Mycite tablets with a strong CYP3A4 or strong CYP2D6 inhibitor, your doctor will likely prescribe a lower Abilify drug dosage. certain HIV drugs, such as ritonavir (Norvir).Here are some strong CYP3A4 and CYP2D6 inhibitor drugs that may interact with Abilify: This can cause Abilify to build up in your system, which may increase the risk of side effects from the drug.Įxamples of strong CYP3A4 and CYP2D6 inhibitors. Drugs that are strong inhibitors of these enzymes slow down the removal of Abilify. CYP3A4 and CYP2D6 help remove Abilify from your body. (For more information about Abilify’s side effects, see this article.) These side effects can include low blood pressure and sleepiness. Taking Abilify with a strong CYP3A4 inhibitor or a strong CYP2D6 inhibitor can increase the risk of side effects of Abilify. Drugs that are strong CYP3A4 inhibitors or strong CYP2D6 inhibitors reduce the activity of these enzymes. (An enzyme is a protein that helps chemical reactions occur.) CYP stands for cytochrome P450. Strong CYP3A4 and CYP2D6 inhibitorsĬYP3A4 and CYP2D6 are enzymes in your liver that help remove certain drugs from your body. Here’s a closer look at certain drug interactions of Abilify. * For more information about the side effects of Abilify, see this article. oxycodone (Oxaydo, Xtampza ER, Ox圜ontin, Roxybond).bupropion (Wellbutrin SR, Wellbutrin XL, Aplenzin)Ĭan increase the risk of low blood pressure with AbilifyĬan increase the risk of sleepiness with Abilify.bupropion ( Wellbutrin SR, Wellbutrin XL, Aplenzin).carbamazepine (Carbatrol, Equetro, Tegretol)Ĭan make Abilify less effective than usualĬan increase the risk of side effects from Abilify*.
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